2022 Challenger Tenis Club Argentino – Singles

This was the first edition of the tournament. The tournament was originally scheduled to be played in Villa Allende but was relocated to Buenos Aires due to operational issues at the venue in Villa Allende.

Francisco Comesaña won the title after defeating Mariano Navone 6–4, 6–0 in the final.

Seeds
• # 🇦🇷 Juan Pablo Ficovich (quarterfinals)

• # 🇧🇷 Felipe Meligeni Alves (semifinals)

• # 🇦🇷 Francisco Comesaña (champion)

• # 🇦🇷 Gonzalo Villanueva (quarterfinals)

• # 🇪🇨 Roberto Quiroz (second round)

• # 🇩🇴 Nick Hardt (second round)

• # 🇹🇳 Malek Jaziri (semifinals)

• # 🇨🇴 Nicolás Mejía (first round)