2022 Challenger de Buenos Aires – Singles

Sebastián Báez was the defending champion but chose not to defend his title.

Juan Manuel Cerúndolo won the title after defeating Camilo Ugo Carabelli 6–4, 2–6, 7–5 in the final.

Seeds
• # 🇦🇷 Federico Coria (first round)

• # 🇩🇪 Daniel Altmaier (second round)

• # 🇵🇪 Juan Pablo Varillas (withdrew)

• # 🇦🇷 Camilo Ugo Carabelli (final)

• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇧🇷 Felipe Meligeni Alves (first round)

• # 🇦🇷 Santiago Rodríguez Taverna (first round)

• # 🇩🇪 Yannick Hanfmann (second round, withdrew)