2022 Challenger de Santiago – Singles

Sebastián Báez was the defending champion but chose not to defend his title.

Hugo Dellien won the title after defeating Alejandro Tabilo 6–3, 4–6, 6–4 in the final.

Seeds
• # 🇨🇿 Jiří Lehečka (quarterfinals)

• # Alejandro Tabilo (final)

• # 🇧🇴 Hugo Dellien (champion)

• # 🇵🇪 Juan Pablo Varillas (semifinals)

• # 🇦🇷 Tomás Martín Etcheverry (semifinals)

• # 🇦🇷 Juan Ignacio Londero (second round)

• # Nicolás Jarry (first round)

• # Tomás Barrios Vera (first round)