2022 Challenger de Villa María

The 2022 Challenger de Villa María was a professional tennis tournament played on clay courts. It was the tournament's first edition, part of the 2022 ATP Challenger Tour. It took place in Villa María, Argentina, between 19 and 25 September 2022.

Seeds

 * 1 Rankings are as of 12 September 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇦🇷 Alex Barrena
 * 🇦🇷 Lautaro Midón
 * 🇦🇷 Juan Bautista Otegui

The following player received entry into the singles main draw as an alternate:
 * 🇦🇷 Facundo Juárez

The following players received entry from the qualifying draw:
 * 🇦🇷 Matías Franco Descotte
 * 🇦🇷 Franco Emanuel Egea
 * 🇦🇷 Alejo Lorenzo Lingua Lavallén
 * 🇧🇷 Orlando Luz
 * 🇦🇷 Ignacio Monzón
 * 🇦🇷 Juan Pablo Paz

Singles

 * 🇦🇷 Nicolás Kicker def. 🇦🇷 Mariano Navone 7–5, 6–3.

Doubles

 * 🇦🇷 Hernán Casanova / 🇦🇷 Santiago Rodríguez Taverna def. 🇦🇷 Facundo Juárez / 🇦🇷 Ignacio Monzón 6–4, 6–3.