2022 Challenger de Villa María – Singles

This was the first edition of the tournament.

Nicolás Kicker won the title after defeating Mariano Navone 7–5, 6–3 in the final.

Seeds
• # 🇵🇪 Juan Pablo Varillas (second round, retired)

• # 🇦🇷 Camilo Ugo Carabelli (second round)

• # 🇦🇷 Facundo Bagnis (semifinals)

• # 🇧🇷 Felipe Meligeni Alves (first round)

• # 🇩🇪 Yannick Hanfmann (quarterfinals)

• # 🇦🇷 Santiago Rodríguez Taverna (first round)

• # 🇦🇷 Renzo Olivo (quarterfinals)

• # 🇦🇷 Juan Manuel Cerúndolo (quarterfinals)