2022 Challenger di Roseto degli Abruzzi II – Singles

Carlos Taberner was the defending champion but lost in the quarterfinals to Tseng Chun-hsin.

Manuel Guinard won the title after defeating Tseng 6–1, 6–2 in the final.

Seeds
• # 🇨🇿 Jiří Veselý (first round)

• # 🇮🇹 Gianluca Mager (first round)

• # 🇪🇸 Carlos Taberner (quarterfinals)

• # 🇫🇷 Corentin Moutet (withdrew)

• # 🇪🇸 Bernabé Zapata Miralles (first round, retired)

• # 🇷🇸 Nikola Milojević (first round)

• # 🇸🇰 Andrej Martin (first round)

• # Tseng Chun-hsin (final)