2022 Charlottesville Men's Pro Challenger – Singles

Stefan Kozlov was the defending champion but lost in the second round to Lucas Gerch.

Ben Shelton won the title after defeating Christopher Eubanks 7–6(7–4), 7–5 in the final.

Seeds
• # 🇺🇸 Denis Kudla (quarterfinals)

• # 🇺🇸 Michael Mmoh (second round)

• # 🇺🇸 Stefan Kozlov (second round)

• # 🇺🇸 Christopher Eubanks (final)

• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇺🇸 Ben Shelton (champion)

• # 🇺🇸 Aleksandar Kovacevic (second round)

• # 🇺🇸 Emilio Nava (semifinals)