2022 Citi Open – Women's singles

Liudmila Samsonova defeated Kaia Kanepi in the final, 4–6, 6–3, 6–3 to win the women's singles tennis title at the 2022 Washington Open. Kanepi was aiming to win her first title since 2013, and to be the oldest player to win a WTA Tour title since Serena Williams in 2020.

Jessica Pegula was the defending champion from when the event was last held in 2019, but lost in the second round to Daria Saville.

Seeds
• #🇺🇸 Jessica Pegula (second round)

• #🇬🇧 Emma Raducanu (quarterfinals)

• #🇷🇴 Simona Halep (second round, retired)

• # Victoria Azarenka (quarterfinals)

• #🇧🇪 Elise Mertens (first round)

• #🇪🇪 Kaia Kanepi (final)

• #🇪🇬 Mayar Sherif (first round)

• # Clara Tauson (first round)

Seeds
• # 🇨🇳 Wang Xiyu (qualifying competition, lucky loser)

• # 🇨🇦 Rebecca Marino (qualified)

• # 🇬🇧 Heather Watson (qualifying competition)

• # 🇪🇸 Cristina Bucșa (qualified)

• # 🇸🇪 Mirjam Björklund (qualified)

• # 🇨🇳 Yuan Yue (first round)

• # 🇺🇸 Caty McNally (qualifying competition)

• # 🇺🇸 Sachia Vickery (qualifying competition)

Qualifiers
• # 🇺🇸 Louisa Chirico

• # 🇨🇦 Rebecca Marino

• # 🇸🇪 Mirjam Björklund

• # 🇪🇸 Cristina Bucșa

Lucky losers
• # 🇨🇳 Wang Xiyu