2022 Città di Como Challenger – Singles

Juan Manuel Cerúndolo was the defending champion but chose not to defend his title.

Cedrik-Marcel Stebe won the title after defeating Francesco Passaro 7–6(7–2), 6–4 in the final.

Seeds
• # 🇮🇹 Marco Cecchinato (first round)

• # 🇮🇹 Giulio Zeppieri (second round)

• # 🇮🇹 Francesco Passaro (final)

• # 🇷🇸 Nikola Milojević (first round)

• # 🇮🇹 Matteo Arnaldi (semifinals, retired)

• # 🇮🇹 Riccardo Bonadio (quarterfinals)

• # 🇮🇹 Stefano Travaglia (first round)

• # 🇮🇹 Andrea Arnaboldi (first round)