2022 Città di Grado Tennis Cup – Singles

Nuria Párrizas Díaz was the defending champion but chose to participate at the 2022 French Open instead.

Elisabetta Cocciaretto won the title, defeating Ylena In-Albon in the final, 6–2, 6–2.

Seeds
• # Ylena In-Albon (final)

• # 🇺🇦 Kateryna Baindl (first round)

• # 🇮🇹 Lucrezia Stefanini (first round)

• # 🇮🇹 Elisabetta Cocciaretto (champion)

• # 🇮🇹 Sara Errani (semifinals)

• # Anastasia Tikhonova (quarterfinals)

• # Stefanie Vögele (first round)

• # Simona Waltert (quarterfinals)