2022 Copa LP Chile – Singles

Anna Bondár was the reigning champion, but chose not to participate.

Mayar Sherif defeated Kateryna Baindl in the final, 3–6, 7–6(7–3), 7–5. This was Sherif's fourth WTA Challenger singles title.

Seeds
• #🇪🇬 Mayar Sherif (champion)

• #🇲🇪 Danka Kovinić (semifinals)

• #🇦🇹 Julia Grabher (quarterfinals)

• # Tamara Zidanšek (second round)

• #🇮🇹 Sara Errani (first round)

• #🇰🇷 Jang Su-jeong (first round)

• #🇦🇩 Victoria Jiménez Kasintseva (quarterfinals)

• #🇺🇸 Emma Navarro (quarterfinals)

Seeds
• # Diana Shnaider (qualified)

• # 🇨🇳 You Xiaodi (qualifying competition)

• # 🇩🇪 Lena Papadakis (qualified)

• # 🇪🇸 Yvonne Cavallé Reimers (qualified)

Qualifiers
• # Diana Shnaider

• # 🇺🇸 Bethanie Mattek-Sands

• # 🇩🇪 Lena Papadakis

• # 🇪🇸 Yvonne Cavallé Reimers