2022 Credit One Charleston Open

The 2022 Charleston Open (branded as the 2022 Credit One Charleston Open for sponsorship reasons) was a women's professional tennis tournament played on outdoor clay courts at the Family Circle Tennis Center on Daniel Island in Charleston, South Carolina. It was the 50th edition of the tournament on the WTA Tour and was classified as a WTA 500 tournament on the 2022 WTA Tour. It was the only event of the clay court season played on green clay.

Singles

 * Belinda Bencic def. 🇹🇳 Ons Jabeur, 6–1, 5–7, 6–4

Doubles

 * Andreja Klepač / 🇵🇱 Magda Linette def. 🇨🇿 Lucie Hradecká / 🇮🇳 Sania Mirza, 6–2, 4–6, [10–7]

Seeds

 * 1 Rankings as of March 21, 2022.

Other entrants
The following players received wildcards into the main draw:
 * 🇨🇿 Linda Fruhvirtová
 * 🇺🇸 Caty McNally
 * 🇺🇸 Emma Navarro
 * Aryna Sabalenka

The following player received entry using a protected ranking into the main draw:
 * 🇺🇦 Katarina Zavatska

The following players received entry from the qualifying draw:
 * 🇺🇸 Robin Anderson
 * 🇺🇸 Sophie Chang
 * 🇺🇸 Francesca Di Lorenzo
 * 🇳🇴 Ulrikke Eikeri
 * 🇺🇦 Nadiia Kichenok
 * 🇺🇸 Allie Kiick
 * 🇷🇴 Gabriela Lee
 * 🇺🇸 Sachia Vickery

The following players received entry as lucky losers:
 * 🇺🇸 CoCo Vandeweghe
 * 🇬🇧 Heather Watson

Withdrawals

 * Before the tournament
 * 🇺🇸 Danielle Collins → replaced by 🇺🇸 Alycia Parks
 * 🇷🇴 Simona Halep → replaced by Anastasia Gasanova
 * Veronika Kudermetova → replaced by 🇺🇸 CoCo Vandeweghe
 * 🇺🇸 Ann Li → replaced by 🇺🇦 Katarina Zavatska
 * 🇨🇿 Tereza Martincová → replaced by 🇨🇳 Wang Xiyu
 * 🇪🇸 Garbiñe Muguruza → replaced by 🇺🇸 Claire Liu
 * Jeļena Ostapenko → replaced by 🇺🇸 Hailey Baptiste
 * 🇪🇸 Nuria Párrizas Díaz → replaced by 🇨🇳 Wang Xinyu
 * 🇩🇪 Andrea Petkovic → replaced by Arianne Hartono
 * Arantxa Rus → replaced by 🇨🇳 Yuan Yue
 * 🇪🇬 Mayar Sherif → replaced by Mariam Bolkvadze
 * 🇺🇦 Elina Svitolina → replaced by 🇵🇱 Magdalena Fręch
 * 🇵🇱 Iga Świątek → replaced by 🇬🇧 Heather Watson
 * Retirements
 * 🇺🇸 Madison Brengle (left knee injury)
 * 🇨🇿 Petra Kvitová (left thigh injury)

Seeds

 * 1 Rankings as of March 21, 2022.

Other entrants
The following pair received a wildcard into the doubles main draw:
 * 🇺🇸 Francesca Di Lorenzo / 🇺🇸 Katie Volynets

Withdrawals

 * Before the tournament
 * 🇺🇦 Lyudmyla Kichenok / Jeļena Ostapenko → replaced by 🇺🇦 Lyudmyla Kichenok / 🇦🇺 Anastasia Rodionova
 * Darija Jurak Schreiber / Andreja Klepač → replaced by  Andreja Klepač / 🇵🇱 Magda Linette
 * Alexa Guarachi / 🇺🇸 Nicole Melichar-Martinez → replaced by 🇰🇿 Anna Danilina / Aliaksandra Sasnovich
 * 🇵🇱 Magda Linette / 🇺🇸 Bernarda Pera → replaced by 🇸🇰 Tereza Mihalíková / 🇨🇿 Květa Peschke