2022 Eastern Kentucky Colonels football team

The 2022 Eastern Kentucky Colonels football team represents Eastern Kentucky University as a member of the ASUN Conference during the 2022 NCAA Division I FCS football season. They are led by Walt Wells in his third season. The Colonels played their home games at Roy Kidd Stadium. On August 28, Wells had a cardiac episode. The following day, Garry McPeek was named the acting head coach.