2022 Emilia-Romagna Open – Women's singles

Mayar Sherif defeated Maria Sakkari in the final, 7–5, 6–3 to win the women's singles tennis title at the 2022 Emilia-Romagna Open. It was her maiden WTA Tour title, and Sherif became the first Egyptian to win a WTA Tour singles title.

Coco Gauff was the reigning champion, but did not participate.

Seeds
• # Maria Sakkari (final)

• # 🇮🇹 Martina Trevisan (first round)

• # 🇷🇴 Irina-Camelia Begu (quarterfinals)

• # 🇺🇸 Sloane Stephens (second round)

• # 🇭🇺 Anna Bondár (first round)

• # 🇷🇴 Ana Bogdan (semifinals)

• # 🇪🇸 Nuria Párrizas Díaz (first round)

• # 🇮🇹 Lucia Bronzetti (first round)

Seeds
• # 🇩🇪 Jule Niemeier (qualified)

• # 🇭🇺 Réka Luca Jani (qualified)

• # Simona Waltert (qualified)

• # 🇸🇰 Anna Karolína Schmiedlová (qualified)

• # 🇺🇦 Kateryna Baindl (qualified)

• # Erika Andreeva (qualified)

• # 🇷🇴 Gabriela Lee (qualifying competition, lucky loser)

• # 🇷🇴 Irina Bara (qualifying competition)

• # Oksana Selekhmeteva (qualifying competition)

• # 🇺🇸 Alycia Parks (qualifying competition)

• # Anastasia Zakharova (first round)

• # 🇦🇷 María Lourdes Carlé (qualifying competition)

Qualifiers
• # 🇩🇪 Jule Niemeier

• # 🇭🇺 Réka Luca Jani

• # Simona Waltert

• # 🇸🇰 Anna Karolína Schmiedlová

• # 🇺🇦 Kateryna Baindl

• # Erika Andreeva

Lucky loser
• # 🇷🇴 Gabriela Lee