2022 Engie Open Andrézieux-Bouthéon 42 – Singles

Harmony Tan was the defending champion but chose not to participate.

Ana Bogdan won the title, defeating Anna Blinkova in the final, 7–5, 6–3.

Seeds
• # 🇫🇷 Clara Burel (first round)

• # 🇫🇷 Océane Dodin (quarterfinals)

• # 🇷🇴 Ana Bogdan (champion)

• # 🇩🇪 Anna-Lena Friedsam (second round)

• # Stefanie Vögele (first round)

• # 🇷🇺 Anna Blinkova (final)

• # 🇬🇧 Katie Boulter (first round)

• # 🇪🇸 Rebeka Masarova (first round)