2022 Engie Open de l'Isère – Singles

Viktorija Golubic was the defending champion but chose not to participate.

Katie Boulter won the title, defeating Anna Blinkova in the final, 7–6(7–2), 6–7(6–8), 6–2.

Seeds
• # Arantxa Rus (quarterfinals)

• # 🇮🇹 Martina Trevisan (quarterfinals)

• # 🇧🇪 Greet Minnen (quarterfinals)

• # 🇫🇷 Chloé Paquet (quarterfinals)

• # 🇺🇦 Daria Snigur (second round)

• # 🇬🇧 Katie Boulter (champion)

• # Ylena In-Albon (first round)

• # 🇷🇺 Anna Blinkova (final)