2022 French Open – Wheelchair quad singles

Niels Vink defeated Sam Schröder in the final, 6–4, 7–6(10–8) to win the quad singles wheelchair tennis title at the 2022 French Open. It was his first major singles title.

Dylan Alcott was the three-time reigning champion, but retired from professional wheelchair tennis in January 2022.

Seeds
• # Niels Vink (champion)

• # Sam Schröder (final)