2022 French Open – Wheelchair women's singles

Defending champion Diede de Groot defeated Yui Kamiji in a rematch of the previous year's final, 6–4, 6–1 to win the women's singles wheelchair tennis title at the 2022 French Open. It was the second step in an eventual Grand Slam for de Groot, and she completed the triple career Grand Slam with the win.

Seeds
• # Diede de Groot (champion)

• # 🇯🇵 Yui Kamiji (final)

• # Aniek van Koot (semifinals)

• # Kgothatso Montjane (semifinals)