2022 Georgia's Rome Challenger – Singles

This was the first edition of the tournament.

Wu Yibing won the title after defeating Ben Shelton 7–5, 6–3 in the final. He did not lose a single set in the entire tournament.

Seeds
• # 🇯🇵 Yoshihito Nishioka (quarterfinals)

• # 🇺🇸 J. J. Wolf (quarterfinals)

• # 🇪🇨 Emilio Gómez (first round)

• # 🇦🇷 Juan Pablo Ficovich (semifinals)

• # Borna Gojo (first round)

• # 🇺🇸 Michael Mmoh (first round)

• # 🇺🇸 Bjorn Fratangelo (quarterfinals)

• # 🇫🇷 Enzo Couacaud (first round, retired)