2022 Grand Prix Hassan II – Singles

David Goffin defeated Alex Molčan in the final, 3–6, 6–3, 6–3 to win the singles tennis title at the 2022 Grand Prix Hassan II. It was Goffin's sixth ATP singles title.

Benoît Paire was the defending champion from when the event was last held in 2019, but withdrew before the beginning of the tournament.

Seeds
• #🇨🇦 Félix Auger-Aliassime (second round)

• #🇬🇧 Dan Evans (first round)

• #🇮🇹 Fabio Fognini (withdrew)

• #🇪🇸 Albert Ramos Viñolas (first round)

• #🇦🇷 Federico Delbonis (first round)

• # Botic van de Zandschulp (quarterfinals)

• #🇪🇸 Alejandro Davidovich Fokina (first round)

• #🇷🇸 Laslo Đere (semifinals)

• # Tallon Griekspoor (first round)

Seeds
• # 🇸🇪 Mikael Ymer (first round)

• # 🇪🇸 Fernando Verdasco (qualifying competition)

• # 🇪🇸 Bernabé Zapata Miralles (qualifying competition, lucky loser)

• # 🇧🇦 Damir Džumhur (qualified)

• # 🇨🇿 Vít Kopřiva (qualified)

• # Pavel Kotov (qualified)

• # 🇮🇹 Gian Marco Moroni (qualifying competition)

• # 🇸🇰 Filip Horanský (first round)

Qualifiers
• # 🇧🇦 Mirza Bašić

• # Pavel Kotov

• # 🇨🇿 Vít Kopřiva

• # 🇧🇦 Damir Džumhur

Lucky loser
• # 🇪🇸 Bernabé Zapata Miralles