2022 Guadalajara Open Akron – Singles

Jessica Pegula defeated Maria Sakkari in the final, 6–2, 6–3 to win the women's singles tennis title at the 2022 Guadalajara Open. Pegula defeated four major champions in succession en route to her first WTA 1000 title, and she saved three match points en route, in her second-round match against Elena Rybakina.

This was the first time that Guadalajara hosted a WTA 1000-level event, having hosted the previous year's WTA Finals.

Seeds
The top eight seeds received a bye into the second round. • 🇪🇸 Paula Badosa (second round, retired)

• Aryna Sabalenka (second round)

• 🇺🇸 Jessica Pegula (champion)

• Maria Sakkari (final)

• 🇺🇸 Coco Gauff (quarterfinals)

• 🇫🇷 Caroline Garcia (third round)

• Daria Kasatkina (third round)

• Veronika Kudermetova (quarterfinals)

• 🇨🇿 Barbora Krejčíková (first round)

• Belinda Bencic (second round)

• 🇧🇷 Beatriz Haddad Maia (first round)

• Jeļena Ostapenko (third round)

• 🇺🇸 Madison Keys (third round)

• 🇺🇸 Danielle Collins (third round)

• Ekaterina Alexandrova (first round)

• 🇨🇿 Petra Kvitová (second round)

Seeds
• # 🇨🇿 Linda Fruhvirtová (qualified)

• # 🇨🇦 Rebecca Marino (qualified)

• # 🇺🇸 Lauren Davis (qualified)

• # 🇦🇹 Julia Grabher (first round)

• # 🇮🇹 Elisabetta Cocciaretto (qualified)

• # 🇧🇷 Laura Pigossi (qualifying competition, lucky loser)

• # 🇺🇸 Alycia Parks (first round)

• # 🇵🇱 Magdalena Fręch (qualified)

• # 🇺🇸 Elizabeth Mandlik (first round)

• # 🇷🇺 Elina Avanesyan (qualifying competition, lucky loser)

• # 🇯🇵 Nao Hibino (qualifying competition, lucky loser)

• # 🇺🇸 CoCo Vandeweghe (qualifying competition, retired)

• # 🇷🇴 Gabriela Lee (first round)

• # 🇩🇪 Anna-Lena Friedsam (first round)

• # 🇦🇷 María Lourdes Carlé (first round)

• # 🇧🇷 Carolina Alves (qualifying competition)

Qualifiers
• # 🇨🇿 Linda Fruhvirtová

• # 🇨🇦 Rebecca Marino

• # 🇺🇸 Lauren Davis

• # 🇺🇸 Kayla Day

• # 🇮🇹 Elisabetta Cocciaretto

• # 🇺🇸 Asia Muhammad

• # 🇺🇸 Caroline Dolehide

• # 🇵🇱 Magdalena Fręch

Lucky losers
• # 🇧🇷 Laura Pigossi

• # 🇷🇺 Elina Avanesyan

• # 🇯🇵 Nao Hibino