2022 Guanajuato Open

The 2022 Guanajuato Open was a professional tennis tournament played on outdoor hard courts. It was the fourteenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Irapuato, Mexico between 7 and 13 March 2022.

Seeds

 * 1 Rankings are as of 28 February 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇮🇹 Gala Arangio
 * 🇲🇽 Claudia Sofía Martínez Solís

The following player received entry as a special exempt:
 * 🇺🇸 Adriana Reami

The following players received entry from the qualifying draw:
 * 🇺🇸 Kaitlyn Christian
 * 🇺🇸 Ellie Douglas
 * 🇺🇸 Dalayna Hewitt
 * 🇲🇽 Jessica Hinojosa Gómez
 * 🇺🇸 Zoe Hitt
 * 🇲🇽 Ana Paula Martínez Mora
 * 🇲🇽 María Fernanda Navarro
 * 🇺🇸 Erica Oosterhout

The following players received entry as lucky losers:
 * 🇨🇴 Ana María Becerra
 * 🇺🇸 Sylvia Schenck

Singles

 * 🇨🇳 Zhu Lin def. 🇨🇦 Rebecca Marino, 6–4, 6–1

Doubles

 * 🇺🇸 Kaitlyn Christian / Lidziya Marozava def.  Anastasia Tikhonova /  Daniela Vismane, 6–0, 6–2