2022 Hall of Fame Open – Singles

Maxime Cressy defeated Alexander Bublik in the final, 2–6, 6–3, 7–6(7–3) to win the men's singles tennis title at the 2022 Hall of Fame Open. It was his maiden ATP Tour title.

Kevin Anderson was the reigning champion, but retired from professional tennis in May 2022.

Seeds
The top four seeds received a bye into the second round. • # 🇨🇦 Félix Auger-Aliassime (second round)

• # 🇺🇸 John Isner (semifinals)

• # 🇰🇿 Alexander Bublik (final)

• # 🇺🇸 Maxime Cressy (champion)

• # 🇫🇷 Benjamin Bonzi (quarterfinals)

• # 🇬🇧 Andy Murray (quarterfinals)

• # 🇨🇿 Jiří Veselý (second round, withdrew)

• # 🇦🇺 James Duckworth (quarterfinals)

Seeds
• # 🇺🇸 Ernesto Escobedo (first round)

• # 🇬🇧 Liam Broady (qualified)

• # 🇺🇸 Mitchell Krueger (qualified)

• # 🇺🇸 Christopher Eubanks (qualified)

• # 🇮🇳 Ramkumar Ramanathan (first round)

• # Wu Tung-lin (first round)

• # Gijs Brouwer (first round)

• # 🇧🇦 Mirza Bašić (qualifying competition)

Qualifiers
• # 🇺🇸 William Blumberg

• # 🇬🇧 Liam Broady

• # 🇺🇸 Mitchell Krueger

• # 🇺🇸 Christopher Eubanks