2022 Hamburg European Open – Men's singles

Lorenzo Musetti defeated Carlos Alcaraz in the final, 6–4, 6–7(6–8), 6–4 to win the men's singles tennis title at the 2022 Hamburg European Open. It was his maiden ATP Tour title, and he saved two match points en route, in his first round match against Dušan Lajović.

Pablo Carreño Busta was the defending champion, but lost in the second round to Alex Molčan.

Seeds
• #🇪🇸 Carlos Alcaraz (final)

• # Andrey Rublev (second round)

• #🇦🇷 Diego Schwartzman (first round)

• #🇪🇸 Pablo Carreño Busta (second round)

• # Botic van de Zandschulp (first round)

• # Nikoloz Basilashvili (first round)

• # Karen Khachanov (quarterfinals)

• # Holger Rune (first round)

Seeds
• # Henri Laaksonen (first round)

• # 🇱🇹 Ričardas Berankis (qualifying competition, lucky loser)

• # 🇨🇴 Daniel Elahi Galán (second round)

• # 🇮🇹 Stefano Travaglia (first round)

• # 🇫🇷 Manuel Guinard (first round)

• # Alexander Shevchenko (qualifying competition)

• # 🇮🇹 Luca Nardi (first round)

• # 🇮🇹 Riccardo Bonadio (qualifying competition)

Qualifiers
• # 🇸🇰 Jozef Kovalík

• # 🇮🇹 Luca Nardi

• # 🇨🇴 Daniel Elahi Galán

• # 🇩🇪 Marko Topo

Lucky loser
• # 🇱🇹 Ričardas Berankis