2022 Hamburg European Open – Women's singles

Bernarda Pera defeated Anett Kontaveit in the final, 6–2, 6–4 to win the women's singles tennis title at the 2022 Hamburg European Open. It was her second WTA Tour title in as many weeks, and she neither dropped a set nor lost more than four games in any set en route to the title.

Elena-Gabriela Ruse was the defending champion, but lost in the first round to Pera.

Seeds
• # 🇪🇪 Anett Kontaveit (final)

• # Daria Kasatkina (first round)

• # 🇨🇿 Barbora Krejčíková (quarterfinals)

• # Aliaksandra Sasnovich (quarterfinals)

• # Tamara Zidanšek (withdrew)

• # Varvara Gracheva (first round)

• # 🇧🇪 Maryna Zanevska (semifinals)

• # 🇩🇪 Andrea Petkovic (quarterfinals, retired)

• # 🇷🇴 Elena-Gabriela Ruse (first round)

Seeds
• # 🇺🇦 Kateryna Baindl (qualifying competition, lucky loser)

• # Anastasia Gasanova (qualifying competition)

• # 🇧🇪 Ysaline Bonaventure (first round)

• # Oksana Selekhmeteva (qualified)

• # 🇦🇷 Paula Ormaechea (first round)

• # Suzan Lamens (qualifying competition, lucky loser)

• # Arianne Hartono (qualifying competition)

• # Joanne Züger (qualified)

• # 🇺🇸 Grace Min (first round)

• # 🇷🇴 Alexandra Cadanțu-Ignatik (qualified)

• # 🇦🇷 María Lourdes Carlé (qualified)

• # Stefanie Vögele (first round)

Qualifiers
• # 🇩🇪 Sabine Lisicki

• # Joanne Züger

• # 🇯🇵 Nao Hibino

• # Oksana Selekhmeteva

• # 🇷🇴 Alexandra Cadanțu-Ignatik

• # 🇦🇷 María Lourdes Carlé

Lucky losers
• # 🇺🇦 Kateryna Baindl

• # Suzan Lamens