2022 Henderson Tennis Open – Singles

Emina Bektas was the defending champion but chose not to participate.

Yuan Yue won the title, defeating Diana Shnaider in the final, 4–6, 6–3, 6–1.

Seeds
• # 🇭🇺 Panna Udvardy (second round)

• # 🇨🇳 Yuan Yue (champion)

• # 🇸🇪 Rebecca Peterson (semifinals)

• # 🇺🇸 Katie Volynets (quarterfinals)

• # 🇺🇸 Asia Muhammad (first round)

• # 🇺🇸 Katrina Scott (first round)

• # 🇦🇺 Astra Sharma (quarterfinals)

• # 🇦🇷 Nadia Podoroska (first round)