2022 I.ČLTK Prague Open – Men's singles

The men's singles of the 2022 I.ČLTK Prague Open tournament took place on clay in Prague, Czech Republic.

Tallon Griekspoor was the defending champion but chose not to compete.

Pedro Cachin won the title after defeating Lorenzo Giustino 6–3, 7–6(7–4) in the final.

Seeds
• # 🇦🇺 Aleksandar Vukic (first round)

• # Nuno Borges (second round)

• # 🇨🇿 Tomáš Macháč (withdrew)

• # 🇨🇿 Vít Kopřiva (second round)

• # 🇦🇷 Pedro Cachin (champion)

• # Jesper de Jong (first round)

• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇮🇹 Federico Gaio (quarterfinals)