2022 IBG Prague Open – Singles

Franco Agamenone was the defending champion but chose not to defend his title.

Oleksii Krutykh won the title after defeating Lucas Gerch 6–3, 6–7(2–7), 6–2 in the final.

Seeds
• # 🇮🇹 Matteo Gigante (quarterfinals)

• # 🇺🇦 Oleksii Krutykh (champion)

• # 🇺🇦 Vitaliy Sachko (second round)

• # 🇪🇸 Oriol Roca Batalla (first round)

• # 🇩🇪 Henri Squire (second round)

• # 🇹🇷 Ergi Kırkın (first round)

• # 🇹🇷 Cem İlkel (first round)

• # 🇺🇸 Nicolas Moreno de Alboran (quarterfinals)