2022 Iași Open – Women's singles

This was the first edition of the tournament.

Ana Bogdan won her first WTA Challenger title, defeating Panna Udvardy in the final, 6–2, 3–6, 6–1.

Seeds
• # Viktorija Golubic (first round)

• # 🇭🇺 Panna Udvardy (final)

• # 🇷🇴 Ana Bogdan (champion)

• # 🇷🇸 Olga Danilović (second round)

• # 🇧🇷 Laura Pigossi (withdrew)

• # 🇫🇷 Kristina Mladenovic (quarterfinals)

• # 🇷🇴 Irina Bara (first round)

• # Ekaterine Gorgodze (quarterfinals)

Seeds
• # 🇯🇵 Yuki Naito (qualified)

• # Darya Astakhova (qualified)

• # 🇷🇴 Cristina Dinu (qualified)

• # 🇷🇴 Ilona Georgiana Ghioroaie (qualified)

• # 🇷🇴 Andreea Roșca (first round)

• # 🇻🇪 Andrea Gámiz (first round, withdrew)

• # 🇷🇴 Elena-Teodora Cadar (qualifying competition)

• # 🇷🇴 Miriam Bulgaru (first round)

Qualifiers
• # 🇯🇵 Yuki Naito

• # Darya Astakhova

• # 🇷🇴 Cristina Dinu

• # 🇷🇴 Ilona Georgiana Ghioroaie

Lucky losers
• # 🇷🇴 Lavinia Tănăsie

• # 🇦🇺 Olivia Tjandramulia