2022 Indianapolis Colts season

The 2022 season was the Indianapolis Colts' 70th in the National Football League (NFL), their 39th in Indianapolis, their sixth under the leadership of general manager Chris Ballard and their fifth and final season under head coach Frank Reich.

In the offseason, the Colts acquired former MVP quarterback Matt Ryan in exchange for a third round pick.

After a 3–5–1 start, head coach Reich was fired from the team with former Colts offensive lineman Jeff Saturday being named the interim head coach. Saturday won his first game with the Colts against the Raiders, but did not win any more games, as the team finished the season on a 7–game losing streak. On December 17, The Colts were defeated by the Minnesota Vikings in a game that was notable for being the biggest blown lead in NFL history, as the Colts squandered a 33–0 halftime lead to lose 39–36 in overtime. This loss, coupled with the Jacksonville Jaguars win over the New York Jets the following Thursday, eliminated the Colts from playoff contention.

Despite the Colts' poor season, one highlight was a week 3 20–17 upset win over the eventual Super Bowl champion Kansas City Chiefs.

Draft
Draft trades

Preseason
The Colts' preseason opponents and schedule were announced in the spring.

Schedule
Note: Intra-division opponents are in bold text.

Week 1: at Houston Texans
This was the Colts first tie game since the 1982 season when they were based in Baltimore. Because the Browns won their season opener for the first time since 2004, coupled with this game, the Colts now hold the NFL's longest active season opener winless streak, not having won a season opener since 2013.

Week 2: at Jacksonville Jaguars
The Colts failed to capitalize on offense, and were shutout for the first time since week 13 of the 2018 season, which was also against the Jaguars. This was also their eighth consecutive loss in Jacksonville.

Week 5: at Denver Broncos
Neither side scored a touchdown as Russell Wilson and Matt Ryan struggled throughout the game. Stephon Gilmore helped win with an interception in the endzone and a mishap by Russell Wilson that he threw to Courtland Sutton while he was covered by Gilmore and ended up being incomplete on 4th down, missing a wide open K.J. Hamler. With the win, the Colts improved to 2–2–1.

Week 9: at New England Patriots
After the game, head coach Frank Reich was fired after a 3-5-1 start, and was replaced by former Colts center Jeff Saturday, who had no coaching experience above the high school level.

Week 15: at Minnesota Vikings
The Colts blew a 33–0 lead and ending up losing in overtime. After the game, Jeff Saturday benched Matt Ryan in favor of Nick Foles for next week's game.

Week 16: vs. Los Angeles Chargers
The Colts were eliminated after the loss.