2022 Internationaux de Strasbourg – Singles

Angelique Kerber defeated Kaja Juvan in the final, 7–6(7–5), 6–7(0–7), 7–6(7–5) to win the singles tennis title at the 2022 Internationaux de Stasborg. It was her 14th WTA Tour singles title. The final lasted 3 hours and 16 minutes.

Barbora Krejčíková was the reigning champion, but withdrew before the tournament.

This was Samantha Stosur's final professional appearance in singles; she lost in the first round to Harmony Tan.

Seeds
• # 🇨🇿 Karolína Plíšková (semifinals)

• # 🇩🇪 Angelique Kerber (champion)

• # 🇷🇴 Sorana Cîrstea (first round)

• # 🇧🇪 Elise Mertens (quarterfinals)

• # 🇨🇳 Zhang Shuai (first round)

• # 🇺🇸 Sloane Stephens (first round)

• # 🇨🇿 Tereza Martincová (withdrew)

• # 🇵🇱 Magda Linette (quarterfinals)

• # Viktorija Golubic (quarterfinals)

Seeds
• # Aliaksandra Sasnovich (qualified)

• # Indy de Vroome (first round)

• # 🇮🇱 Lina Glushko (qualified)

• # 🇩🇪 Katharina Hobgarski (qualifying competition, lucky loser)

• # 🇧🇦 Nefisa Berberović (first round, lucky loser)

• # Ekaterina Makarova (qualified)

• # 🇩🇪 Lena Papadakis (qualifying competition)

• # 🇧🇪 Magali Kempen (first round)

Qualifiers
• # Aliaksandra Sasnovich

• # Ekaterina Makarova

• # 🇮🇱 Lina Glushko

• # 🇫🇷 Julie Gervais

Lucky losers
• # 🇩🇪 Katharina Hobgarski

• # 🇩🇪 Yana Morderger

• # Angelina Gabueva

• # 🇧🇦 Nefisa Berberović