2022 Internationaux de Tennis de Blois – Singles

Pedro Sousa was the defending champion but chose not to defend his title.

Alexandre Müller won the title after defeating Nikola Milojević 7–6(7–3), 6–1 in the final.

Seeds
• # 🇨🇿 Zdeněk Kolář (first round)

• # 🇫🇷 Corentin Moutet (first round)

• # 🇦🇷 Camilo Ugo Carabelli (second round)

• # 🇦🇷 Pedro Cachin (first round)

• # 🇨🇿 Vít Kopřiva (semifinals)

• # 🇦🇹 Dennis Novak (second round)

• # 🇷🇸 Nikola Milojević (final)

• # Nino Serdarušić (second round)