2022 Internationaux de Tennis de Vendée – Singles

Jiří Veselý was the defending champion but chose not to defend his title.

Jelle Sels won the title after defeating Vasek Pospisil 6–4, 6–3 in the final.

Seeds
• # 🇨🇿 Jiří Lehečka (second round, retired)

• # 🇺🇸 J. J. Wolf (quarterfinals)

• # 🇫🇷 Hugo Gaston (semifinals)

• # 🇫🇷 Richard Gasquet (first round)

• # 🇫🇷 Quentin Halys (withdrew)

• # 🇫🇷 Hugo Grenier (first round)

• # 🇸🇰 Norbert Gombos (quarterfinals)

• # 🇨🇿 Tomáš Macháč (quarterfinals)