2022 Internazionali Femminili di Brescia – Singles

Jasmine Paolini was the defending champion but chose not to participate.

Ángela Fita Boluda won the title, defeating Despina Papamichail in the final, 6–2, 6–0.

Seeds
• # Ylena In-Albon (quarterfinals)

• # 🇪🇸 Rebeka Masarova (first round)

• # 🇨🇳 Yuan Yue (second round, withdrew)

• # 🇩🇪 Nastasja Schunk (withdrew)

• # Despina Papamichail (final)

• # Stefanie Vögele (second round)

• # 🇮🇹 Sara Errani (quarterfinals)

• # Bárbara Gatica (withdrew)