2022 Internazionali Femminili di Palermo – Singles

Irina-Camelia Begu defeated Lucia Bronzetti in the final, 6–2, 6–2 to win the singles tennis title at the 2022 Internazionali Femminili di Palermo. It was her fifth career WTA Tour singles title, her first since 2017. Bronzetti was contesting her first career singles final.

Danielle Collins was the reigning champion, but did not participate.

Seeds
• # 🇮🇹 Martina Trevisan (withdrew)

• # 🇰🇿 Yulia Putintseva (second round)

• # 🇨🇳 Zhang Shuai (second round, withdrew)

• # 🇪🇸 Sara Sorribes Tormo (semifinals)

• # 🇫🇷 Caroline Garcia (quarterfinals)

• # 🇷🇴 Irina-Camelia Begu (champion)

• # 🇭🇺 Anna Bondár (quarterfinals)

• # 🇪🇸 Nuria Párrizas Díaz (quarterfinals)

Seeds
• # 🇷🇴 Ana Bogdan (moved to main draw)

• # Ylena In-Albon (moved to main draw)

• # Elina Avanesyan (qualified)

• # 🇪🇸 Rebeka Masarova (qualified)

• # 🇦🇹 Julia Grabher (qualifying competition, lucky loser)

• # 🇷🇴 Gabriela Lee (first round)

• # 🇦🇺 Jaimee Fourlis (qualifying competition, lucky loser)

• # 🇫🇷 Léolia Jeanjean (qualified)

• # Anastasia Zakharova (first round)

• # 🇺🇸 Asia Muhammad (qualified)

• # 🇧🇷 Carolina Alves (qualifying competition, lucky loser)

• # Anastasia Tikhonova (qualifying competition)

Qualifiers
• # 🇪🇸 Marina Bassols Ribera

• # 🇺🇸 Asia Muhammad

• # Elina Avanesyan

• # 🇪🇸 Rebeka Masarova

• # 🇫🇷 Léolia Jeanjean

• # 🇮🇹 Matilde Paoletti

Lucky losers
• # 🇦🇺 Jaimee Fourlis

• # 🇦🇹 Julia Grabher

• # 🇧🇷 Carolina Alves