2022 Internazionali Femminili di Tennis Città di Caserta – Singles

Varvara Gracheva was the defending champion but chose not to participate.

Kristina Mladenovic won the title, defeating Camilla Rosatello in the final, 6–4, 4–6, 7–6(7–3).

Seeds
• # 🇫🇷 Clara Burel (first round)

• # 🇫🇷 Kristina Mladenovic (champion)

• # Elina Avanesyan (second round)

• # Despina Papamichail (first round)

• # 🇯🇵 Moyuka Uchijima (semifinals)

• # Simona Waltert (first round)

• # 🇮🇹 Federica Di Sarra (quarterfinals)

• # Daniela Vismane (quarterfinals)