2022 Internazionali di Tennis Castel del Monte – Singles

Ugo Humbert was the defending champion but chose not to defend his title.

Leandro Riedi won the title after defeating Mikhail Kukushkin 7–6(7–4), 6–3 in the final.

Seeds
• # 🇭🇺 Márton Fucsovics (semifinals)

• # 🇫🇷 Hugo Gaston (first round)

• # 🇨🇿 Tomáš Macháč (quarterfinals)

• # 🇺🇸 Michael Mmoh (withdrew)

• # 🇦🇹 Jurij Rodionov (quarterfinals)

• # 🇸🇪 Elias Ymer (first round)

• # Jelle Sels (second round, retired)

• # 🇧🇪 Zizou Bergs (second round)