2022 Internazionali di Tennis Città di Todi – Singles

Mario Vilella Martínez was the defending champion but chose not to defend his title.

Pedro Cachin won the title after defeating Nicolás Kicker 6–4, 6–4 in the final.

Seeds
• # 🇦🇷 Pedro Cachin (champion)

• # 🇮🇹 Flavio Cobolli (quarterfinals)

• # 🇫🇷 Alexandre Müller (first round)

• # Nino Serdarušić (second round)

• # 🇦🇷 Santiago Rodríguez Taverna (quarterfinals)

• # 🇸🇰 Filip Horanský (first round)

• # 🇦🇷 Thiago Agustín Tirante (second round)

• # 🇰🇿 Dmitry Popko (first round)