2022 Internazionali di Tennis Città di Trieste – Singles

Tomás Martín Etcheverry was the defending champion but chose not to defend his title.

Francesco Passaro won the title after defeating Zhang Zhizhen 4–6, 6–3, 6–3 in the final.

Seeds
• # 🇸🇰 Norbert Gombos (quarterfinals)

• # 🇮🇹 Franco Agamenone (quarterfinals)

• # 🇮🇹 Gianluca Mager (first round)

• # 🇦🇹 Dennis Novak (first round)

• # 🇮🇹 Marco Cecchinato (second round)

• # 🇷🇸 Nikola Milojević (first round)

• # 🇦🇷 Santiago Rodríguez Taverna (second round)

• # 🇫🇷 Alexandre Müller (semifinals)