2022 Internazionali di Tennis Città di Vicenza – Singles

Alessandro Giannessi was the defending champion but chose not to defend his title.

Andrea Pellegrino won the title after defeating Andrea Collarini 6–1, 6–4 in the final.

Seeds
• # 🇮🇹 Gianluca Mager (quarterfinals)

• # 🇦🇷 Juan Manuel Cerúndolo (quarterfinals)

• # 🇮🇹 Andreas Seppi (first round)

• # 🇮🇹 Flavio Cobolli (second round)

• # 🇦🇷 Renzo Olivo (second round)

• # 🇰🇿 Dmitry Popko (first round)

• # 🇮🇹 Lorenzo Giustino (first round)

• # 🇮🇹 Salvatore Caruso (first round)