2022 Internazionali di Tennis d'Abruzzo – Singles

Stefano Travaglia was the defending champion but chose not to defend his title.

Matteo Arnaldi won the title after defeating Francesco Maestrelli 6–3, 6–7(7–9), 6–4 in the final.

Seeds
• # 🇺🇸 Nicolas Moreno de Alboran (withdrew)

• # 🇭🇺 Máté Valkusz (quarterfinals, retired)

• # 🇧🇷 Daniel Dutra da Silva (second round)

• # 🇮🇹 Matteo Arnaldi (champion)

• # 🇨🇦 Alexis Galarneau (semifinals)

• # 🇦🇷 Hernán Casanova (semifinals, retired)

• # 🇫🇷 Mathias Bourgue (quarterfinals)

• # 🇩🇴 Nick Hardt (first round)

• # 🇺🇦 Oleksii Krutykh (first round)