2022 Internazionali di Tennis del Friuli Venezia Giulia – Men's singles

Francisco Cerúndolo was the defending champion but chose not to defend his title.

Zhang Zhizhen won the title after defeating Andrea Vavassori 2–6, 7–6(7–5), 6–3 in the final.

Seeds
• # 🇷🇸 Laslo Đere (second round)

• # 🇦🇷 Juan Manuel Cerúndolo (first round)

• # 🇦🇷 Camilo Ugo Carabelli (first round)

• # Pavel Kotov (first round)

• # 🇮🇹 Flavio Cobolli (first round)

• # 🇨🇿 Zdeněk Kolář (first round)

• # 🇫🇷 Alexandre Müller (semifinals)

• # 🇮🇹 Marco Cecchinato (first round)