2022 Istanbul Challenger – Singles

James Duckworth was the defending champion but lost in the first round to Lukáš Rosol.

Radu Albot won the title after defeating Rosol 6–2, 6–0 in the final.

Seeds
• # 🇦🇺 James Duckworth (first round)

• # 🇲🇩 Radu Albot (champion)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇫🇷 Geoffrey Blancaneaux (semifinals)

• # 🇬🇧 Paul Jubb (first round)

• # 🇫🇷 Laurent Lokoli (quarterfinals)

• # 🇦🇹 Sebastian Ofner (quarterfinals)

• # 🇪🇸 Nicolás Álvarez Varona (second round)