2022 Italian Open – Men's singles

Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–0, 7–6(7–5) to win the men's singles tennis title at the 2022 Italian Open. It was his sixth Italian Open title and record-extending 38th Masters 1000 title overall. Djokovic did not lose a set during the tournament, and won his 1000th ATP Tour-level career match against Casper Ruud in the semifinals.

Rafael Nadal was the defending champion, but lost in the third round to Denis Shapovalov.

Djokovic and Daniil Medvedev were in contention for the ATP No. 1 singles ranking. Djokovic retained the top position by reaching the semifinals.

Seeds
The top eight seeds received a bye into the second round. • 🇷🇸 Novak Djokovic (champion)

• 🇩🇪 Alexander Zverev (semifinals)

• 🇪🇸 Rafael Nadal (third round)

• Stefanos Tsitsipas (final)

• 🇳🇴 Casper Ruud (semifinals)

•  Andrey Rublev (second round)

• 🇪🇸 Carlos Alcaraz (withdrew)

• 🇨🇦 Félix Auger-Aliassime (quarterfinals)

• 🇬🇧 Cameron Norrie (second round)

• 🇮🇹 Jannik Sinner (quarterfinals)

• 🇵🇱 Hubert Hurkacz (first round)

• 🇦🇷 Diego Schwartzman (second round)

• 🇨🇦 Denis Shapovalov (quarterfinals)

• 🇺🇸 Reilly Opelka (first round)

• 🇪🇸 Pablo Carreño Busta (second round)

• 🇪🇸 Roberto Bautista Agut (withdrew)

Finals


Seeded players
The following are the seeded players. Seedings are based on ATP rankings as of 2 May 2022. Rankings and points before are as of 9 May 2022.

As a result of special ranking adjustment rules due to the COVID-19 pandemic, players are defending the higher of (i) their points from the 2021 tournament or (ii) the remaining 50% of their points from the 2020 tournament. Those points were not mandatory and are included in the table below only if they counted towards the player's ranking as of May 9, 2022. Players who are not defending points from the 2021 or 2020 tournaments will instead have their 19th best result replaced by their points from the 2022 tournament.

† This column shows either (a) the higher of the player's points from the 2021 tournament or 50% of his points from the 2020 tournament, or (b) his 19th best result (shown in brackets). Only ranking points counting towards the player's ranking as of May 9, 2022, are reflected in the column.

Withdrawn players
The following players would have been seeded, but withdrew before the tournament began.

Wildcards
• 🇮🇹 Matteo Arnaldi

• 🇮🇹 Flavio Cobolli

• 🇮🇹 Luca Nardi

• 🇮🇹 Francesco Passaro

Protected ranking
• Borna Ćorić

• 🇦🇹 Dominic Thiem

•  Stan Wawrinka

Withdrawals
• 🇪🇸 Carlos Alcaraz → replaced by 🇫🇮 Emil Ruusuvuori

• 🇪🇸 Roberto Bautista Agut → replaced by 🇺🇸 Marcos Giron

• 🇮🇹 Matteo Berrettini → replaced by 🇺🇸 Sebastian Korda

• 🇺🇸 Taylor Fritz → replaced by 🇪🇸 Pedro Martínez

• Daniil Medvedev → replaced by  Ilya Ivashka

• 🇫🇷 Gaël Monfils → replaced by 🇪🇸 Alejandro Davidovich Fokina

Seeds
• # 🇦🇷 Sebastián Báez (qualified)

• # Holger Rune (first round)

• # 🇫🇷 Ugo Humbert (first round)

• # 🇸🇰 Alex Molčan (first round)

• # 🇦🇷 Francisco Cerúndolo (qualified)

• # 🇭🇺 Márton Fucsovics (qualifying competition, retired)

• # 🇺🇸 Marcos Giron (qualifying competition, lucky loser)

• # 🇷🇸 Laslo Đere (qualified)

• # 🇺🇸 Mackenzie McDonald (first round)

• # Tallon Griekspoor (qualified)

• # 🇦🇷 Federico Coria (first round)

• # 🇫🇮 Emil Ruusuvuori (qualifying competition, lucky loser)

• # 🇫🇷 Benoît Paire (first round)

• # 🇺🇸 Maxime Cressy (qualifying competition)

Qualifiers
• # 🇦🇷 Sebastián Báez

• # 🇷🇸 Laslo Đere

• # 🇺🇸 Brandon Nakashima

• # 🇮🇹 Giulio Zeppieri

• # 🇦🇷 Francisco Cerúndolo

• # 🇷🇸 Dušan Lajović

• # Tallon Griekspoor

Lucky losers
• # 🇺🇸 Marcos Giron

• # 🇫🇮 Emil Ruusuvuori