2022 Karlsruhe Open – Singles

Mayar Sherif was the defending champion and successfully defended her title, defeating Bernarda Pera in the final, 6–2, 6–4.

Seeds
• # 🇧🇪 Alison Van Uytvanck (second round)

• # 🇪🇬 Mayar Sherif (champion)

• # 🇭🇺 Anna Bondár (semifinals)

• # 🇧🇪 Greet Minnen (second round, withdrew)

• # 🇭🇺 Panna Udvardy (quarterfinals)

• # 🇫🇷 Clara Burel (first round)

• # 🇭🇺 Dalma Gálfi (quarterfinals)

• # 🇺🇸 Bernarda Pera (final)