2022 Knoxville Challenger

The 2022 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the 18th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Knoxville, United States between 7 and 13 November 2022.

Seeds

 * 1 Rankings are as of October 31, 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇯🇲 Blaise Bicknell
 * 🇺🇸 Gage Brymer
 * 🇺🇸 Martin Damm

The following player received entry into the singles main draw as an alternate:
 * 🇺🇸 Ethan Quinn

The following players received entry from the qualifying draw:
 * 🇺🇸 Alexander Bernard
 * 🇬🇧 Giles Hussey
 * 🇺🇸 Cannon Kingsley
 * 🇺🇸 Strong Kirchheimer
 * 🇺🇸 Tristan McCormick
 * 🇪🇸 Iñaki Montes de la Torre

Singles

 * 🇺🇸 Ben Shelton def. 🇺🇸 Christopher Eubanks 6–3, 1–6, 7–6(7–4).

Doubles

 * 🇺🇸 Hunter Reese / 🇺🇸 Tennys Sandgren def. 🇺🇸 Martin Damm / 🇺🇸 Mitchell Krueger 6–7(4–7), 7–6(7–3), [10–5].