2022 Knoxville Challenger – Doubles

Malek Jaziri and Blaž Rola were the defending champions but chose not to defend their title.

Hunter Reese and Tennys Sandgren won the title after defeating Martin Damm and Mitchell Krueger 6–7(4–7), 7–6(7–3), [10–5] in the final.

Seeds
• # 🇬🇧 Julian Cash / 🇬🇧 Henry Patten (semifinals)

• # 🇮🇳 Sriram Balaji / 🇮🇳 Jeevan Nedunchezhiyan (semifinals)

• # 🇺🇸 Alex Lawson / 🇳🇿 Artem Sitak (quarterfinals)

• # 🇫🇷 Théo Arribagé / 🇬🇧 Luke Johnson (first round)