2022 Knoxville Challenger – Singles

Christopher Eubanks was the defending champion but lost in the final to Ben Shelton.

Shelton won the title after defeating Eubanks 6–3, 1–6, 7–6(7–4) in the final.

Seeds
• # 🇺🇸 Michael Mmoh (semifinals)

• # 🇺🇸 Stefan Kozlov (quarterfinals)

• # 🇺🇸 Christopher Eubanks (final)

• # 🇺🇸 Ben Shelton (champion)

• # 🇺🇸 Emilio Nava (first round)

• # 🇺🇸 Aleksandar Kovacevic (quarterfinals)

• # 🇫🇷 Enzo Couacaud (semifinals)

• # 🇨🇳 Shang Juncheng (first round)