2022 Kuchyně Gorenje Prague Open – Singles

Magdalena Fręch was the defending champion, but chose to compete at the US Open instead.

Réka Luca Jani won the title, defeating Noma Noha Akugue in the final, 6–3, 7–6(7–4).

Seeds
All seeds receive a bye into the second round. • # 🇦🇹 Julia Grabher (quarterfinals)

• # 🇭🇺 Réka Luca Jani (champion)

• # 🇦🇷 María Lourdes Carlé (semifinals)

• # Despina Papamichail (second round)

• # 🇨🇿 Jesika Malečková (third round)

• # 🇲🇰 Lina Gjorcheska (second round)

• # 🇧🇦 Dea Herdželaš (third round)

• # 🇹🇷 Çağla Büyükakçay (third round)

• # 🇫🇷 Carole Monnet (second round)

• # 🇪🇸 Ángela Fita Boluda (quarterfinals)

• # Lea Bošković (second round)

• # 🇧🇷 Gabriela Cé (second round)

• # Eva Vedder (third round)

• # 🇪🇸 Irene Burillo Escorihuela (third round)

• # Daniela Seguel (second round)

• # Vera Lapko (second round)