2022 LTP Charleston Pro Tennis 2 – Singles

Despina Papamichail was the defending champion but lost in the second round to Victoria Duval.

Carol Zhao won the title, defeating Himeno Sakatsume in the final, 3–6, 6–4, 6–4.

Seeds
• # 🇺🇸 Alycia Parks (second round)

• # Despina Papamichail (second round)

• # 🇨🇿 Linda Fruhvirtová (quarterfinals)

• # 🇺🇸 Caroline Dolehide (second round)

• # Joanne Züger (second round)

• # 🇺🇸 Jamie Loeb (first round)

• # 🇺🇸 Emma Navarro (second round)

• # 🇲🇽 Marcela Zacarías (second round)